Injection device with an acoustic feedback arrangement

ABSTRACT

An injection device for setting and injecting of a dose of a medicament includes: an acoustic feedback arrangement comprising: a first feedback element having a first engaging section and having a free end section located at a predetermined distance from the first engaging section, a second feedback element having a second engaging section configured to engage with the first engaging section, wherein the first feedback element is movable, pivotable or resiliently deformable along a first direction (d1) relative to the second feedback element from an initial state (i) towards a biased state (b), and a sound generator formed by the first engaging section or audibly engageable with the free end section of the first feedback element.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is the national stage entry of InternationalPatent Application No. PCT/EP2018/056029, filed on Mar. 12, 2018, andclaims priority to European Application No. EP 17305270.5, filed on Mar.14, 2017, the disclosures of which are incorporated herein by reference.

TECHNICAL FIELD

The present disclosure relates to an injection device with an acousticfeedback arrangement. In one aspect, the disclosure relates to a handheld injection device, such as pen-type injector for setting anddispensing of a dose of a medicament. The injection device is equippedwith an acoustic feedback arrangement to provide acoustic and audiblefeedback to a user when using the injection device. The acousticfeedback arrangement is particularly dedicated to provide an audible andhence an acoustic signal at the end of a dose dispensing procedureconducted and executed by the injection device.

BACKGROUND

Injection devices for setting and dispensing a single or multiple dosesof a liquid medicament are as such well-known in the art. Generally,such devices have substantially a similar purpose as that of an ordinarysyringe.

Injection devices, in particular pen-type injectors have to meet anumber of user-specific requirements. For instance, with patient'ssuffering chronic diseases, such as diabetes, the patient may bephysically infirm and may also have impaired vision. Suitable injectiondevices especially intended for home medication therefore need to berobust in construction and should be easy to use. Furthermore,manipulation and general handling of the device and its componentsshould be intelligible and easy understandable. Moreover, the dosesetting and the dose dispensing procedure must be easy to operate andhas to be unambiguous.

Typically, such devices comprise a housing including a particularcartridge holder, adapted to receive a cartridge at least partiallyfilled with the medicament to be dispensed. Such devices furthercomprise a drive mechanism, usually having a displaceable piston rodwhich is adapted to operably engage with a piston or bung of thecartridge. By means of the drive mechanism and its piston rod, the bungor piston of the cartridge is displaceable in a distal direction ordispensing direction and may therefore expel a predefined amount of themedicament via a piercing assembly, which is to be releasably coupledwith a distal end section of the housing of the injection device.

The medicament to be dispensed by the injection device is provided andcontained in a multi-dose cartridge. Such cartridges typically comprisea vitreous barrel sealed in a distal direction by means of a pierceableseal and being further sealed in proximal direction by the bung. Withreusable injection devices an empty cartridge is replaceable by a newone. In contrast, injection devices of disposable type are to bediscarded when the medicament in the cartridge has been dispensed orused-up.

During an injection procedure the medicament expelled through aninjection needle is injected into biological tissue of the patient. Inorder to ensure a complete administering of a dose of the medicament itis required to keep the needle for a while in the injection site of thebiological tissue after the dose dispensing process is terminated.Typically, the patient has to wait for a predetermined hold time, e.g. afew seconds, before the injection needle can be withdrawn from thetissue. For this but also in general it is desirable to audibly indicateto the user of the device when the process of dose dispensing hasterminated.

Known devices may provide a particular sound or a klick signal as anindication that the complete dose has been administered.

Especially with purely mechanically implemented injection devices aparticular end of dose sound produced by the device may be difficult toperceive, especially for patients suffering a hearing loss. It istherefore desirable to improve the acoustic properties of an injectiondevice especially in terms of an acoustic or audibly perceivable end ofdose indication. The injection device should provide a clear anddistinct sound or an acoustic signal at the end of a dose dispensingprocedure. For this, the injection device should provide an acousticfeedback arrangement that is easy and straightforward to implement, evenwith existing designs of injection devices. The feedback arrangementshould provide a simple and cost efficient approach to improve theaudible and acoustic feedback of the injection device.

SUMMARY

In one aspect an injection device is provided for setting and injectingof a dose of a medicament. The injection device comprises an acousticfeedback arrangement. The acoustic feedback arrangement comprises afirst feedback element having a first engaging section and furtherhaving a free end section that is located at a predetermined distancefrom the first engaging section. The acoustic feedback arrangementfurther comprises a second feedback element having a second engagingsection that is configured to engage with the first engaging section.The first and the second engaging sections are configured tomechanically engage, i.e. to get in mutual mechanical contact.

The first feedback element is movable, pivotable or resilientlydeformable along a first direction relative to the second feedbackelement. The first feedback element is movable, pivotable or resilientlydeformable from an initial state towards a biased state. The acousticfeedback arrangement further comprises a sound generator that is eitherformed by the first engaging section or which is audibly engageable withthe free end section of the first feedback element. When audiblyengageable with the free end section of the first feedback element thesound generator may be provided as a separate part from the firstfeedback element. It may be connected to or may be integrated into thesecond feedback element. When the sound generator is formed by the firstengaging section, the sound generator is integrated into the firstfeedback element.

When the sound generator is exclusively formed and provided by the firstengaging section the free end section of the first feedback elementprovides an acoustic amplification of the sound generated by the soundgenerator. In some embodiments the free end section is free to vibrateand may hence amplify an acoustically perceivable sound generated by themutual engagement of the first engaging section and the second engagingsection of first and second feedback elements, respectively.Consequently and due to the acoustic amplification provided by the freeend section of the first feedback element a sound pressure or a loudnessof the sound generated by the mutual interaction of the first and thesecond engaging sections can be increased compared to solutions whereina free end section of a first feedback element is audibly engaged with asecond feedback element.

In some embodiments, wherein the sound generator is formed and providedby a separate part of the acoustic feedback arrangement or of theinjection device the free end section of the first feedback elementprovides and behaves as a clapper, as a tongue or as a mallet,temporally mechanically and acoustically engaging with the soundgenerator. Here, the free end section of the first feedback element isconfigured to strike the sound generator in order to produce awell-defined audible and acoustically perceivable feedback signal orfeedback sound.

In some examples, the first engaging section is configured to audiblyengage with the second engaging section when the first feedback elementreturns from the biased state to the initial state. In the biased statethe first feedback element may be pre-tensed or biased compared to theinitial state, in which the first feedback element may be in a relaxedstate. The first feedback element may be resiliently deformable againsta restoring force from the initial state towards the biased state. Whenreleased from the biased state the first feedback element may returninto the initial state under the effect of the restoring force. In someexamples, the first feedback element may be relatively stiff and rigid.It may be then pivotally or movably arranged relative to the secondfeedback element. Then, the first feedback element may be pivotable ordisplaceable against a restoring force from the initial state to thebiased state. The first feedback element may be engaged with a restoringelement, such as a spring element, providing a restoring force todisplace or to pivot the first feedback element from the biased state tothe initial state.

The first engaging section and the second engaging section arecomplementary or correspondingly shaped so as to generate a well-definedand specific audible and acoustically perceivable signal when the firstfeedback element returns from the biased state to the initial state. Inthe initial state or prior to reaching the initial state the firstengaging section and the second engaging section mechanically andaudibly engage.

According to some examples, the free end section of the first feedbackelement is free of contact to any other component of the injectiondevice or of the acoustic feedback arrangement when the first feedbackelement is in the initial state. When in the initial state, the firstengaging section and the second engaging section may be in mutualabutment but the free end section of the first feedback element iscontact-less to any other component of the acoustic feedback arrangementor of the injection device. In this way, the free end section of thefirst feedback element is enabled to vibrate substantially undamped orunmuted. An acoustic noise or acoustic sound generated by the mechanicalinteraction of the first engaging section and the second engagingsection may propagate towards the free end section of the first feedbackelement and may emanate therefrom to the environment. The contactlessmounting or suspension of the free end section inside the injectiondevice provides an acoustic amplification of an acoustic signalgenerated by the mechanical engagement of the first and second engagingsections of the first and the second feedback elements.

In some examples, the free end section of the first feedback element istransferable to a vibrational state. When stimulated to vibrate thevibration of the free end section of the first feedback element servesto enhance and to amplify an acoustically perceivable signal generatedby the mechanical engagement of the first and the second engagingsections. A vibration of the free end section can be stimulated throughthe mechanical interaction of the first and the second engagingsections. When in the vibrational state the first feedback elementitself may be subject to an acoustically or even haptically perceivablevibration. The vibration of the first feedback element, in particularthe vibration of its free end section, may amplify an acoustic noise oracoustic sound generated by the mechanical engagement of the firstengaging section with the second engaging section. Moreover, thevibration of the first feedback element may serve to strike the soundgenerator, if the sound generator is provided as a separate part fromthe first feedback element.

In addition and in some examples, the first feedback element and/or itsfree end section may comprise a resonance frequency that is in the rangeof the frequency of an acoustic signal that arises when the first andthe second engaging sections mutually engage. In this way, the resonanceor the resonant behavior of the first feedback element provides anamplification of an acoustic signal generated by the mutual engagementof the first engaging section and the second engaging section.

In some examples, the first feedback element comprises a body having atleast one hollow portion at the free end section. The hollow portion maycomprise a resonance frequency or may exhibit an eigenfrequency thatsubstantially matches with the frequency of the acoustic sound generatedby the mutual engagement of the first engaging section and the secondengaging section. In this way, the hollow portion of the feedbackelement is configured to provide acoustic amplification of the acousticsignal generated by the first and the second engaging sections.

In some examples, the first feedback element comprises a curved sectionlocated between the engaging section and the free end section. Thecurved section may provide a specific acoustic amplification. The curvedsection may further have a specific and well-defined resonance frequencyin response to mechanical stimulation or mechanical vibration that ise.g. provided by the mutual mechanical engagement of the first engagingsection and the second engaging section. Moreover, the curved sectionmay exhibit a well-defined vibrational behavior inducible by themechanical engagement of the first and the second engaging sections.

The curved section may inherently provide an acoustic amplification ofan acoustic signal emanating from the first engaging section. It is evenconceivable, that a portion of the curved section, in particular thefree end of the curved section is hollow. The curved section maycomprise an increasing cross-section or an increasing hollow diametertowards the free end section. In this way the curved section and/or thefree end section of the first feedback element may provide a kind of atrumpet bell inherently providing an amplification of audible sound.

In some examples, the free end section comprises a contact surfaceconfigured to audibly engage with the sound generator when the firstfeedback element returns from the biased rates to the initial state. Thecontact surface may form the very end of the free end section. When forinstance the free end section is stimulated to vibrate it is the contactsurface that exhibits the largest vibration amplitude of the firstfeedback element. Providing a maximum vibration amplitude at the freeend of the first feedback element is beneficial to strike a separatesound generator. In this way, the mechanical momentum when striking thesound generator can be maximized. In effect, a well-defined anddistinguishable sound can be generated by the sound generator.

In some examples, the sound generator is transferable to a vibrationalstate through engagement with the first feedback element. Here, thefirst feedback element acts and behaves as a clapper, as a tongue or asa mallet configured to strike the sound generator. Typically, the firstfeedback element is configured to temporally strike the sound generatorso that after a striking event the sound generator is free to vibrate inorder to provide a long-lasting substantially undamped slowlyattenuating noise or sound.

By providing a sound generator separate from the first and the secondfeedback element a large variety of different characteristic sounds canbe generated and designed. For instance, the sound generator may exhibita reverb effect. It may provide and exhibit a chime sound or a sound ofa bell.

In some configurations, the first feedback element and its free endsection is located at a well-defined distance from the separate soundgenerator when the first feedback element is in its initial state.Striking of the sound generator by returning from the biased state tothe initial state may be due to a temporary over shooting of the soundgenerator beyond the initial state when returning from the biased statetowards the initial state.

In some examples, the second feedback element is configured to transferthe first feedback element from the initial state towards and into thebiased state. In this way, a relative movement of the first feedbackelement and the second feedback element serves to transfer the firstfeedback element from the initial state towards and into the biasedstate. A further movement of the first feedback element relative to thesecond feedback element then leads to the returning of the firstfeedback element into the initial state. Typically, the first feedbackelement is translationally displaceable relative to the second feedbackelement or the first feedback element is rotationally displaceablerelative to the second feedback element. It is even conceivable, thatthe first feedback element is both, translationally and rotationallymovable relative to the second feedback element. Typically, one of thefirst and the second feedback elements is stationary during dispensingof a dose of the medicament while the other one of the first and thesecond feedback elements is subject to a movement.

In some configurations, the first and the second feedback elements aremovable relative to each other with respect to a second direction thatdiffers from the first direction along which the first feedback elementis movable, pivotable or resiliently deformable. The mutual interactionof the first and the second feedback element may be configured such,that a displacement or movement of the first feedback element relativeto the second feedback element along the second direction leads to andinduces a movement, a pivoting or a resilient deformation of the firstfeedback element along the first direction. The first and seconddirections may be oriented perpendicular to each other.

With a cylindrically shaped injection device it is for instanceconceivable that the first feedback element is axially displaceablerelative to the second feedback element and that the first feedbackelement, due to engagement with the second feedback element, is subjectto a radial or circumferential pivoting, movement or resilientdeformation. In other examples the first feedback element may berotationally displaceable relative to the second feedback element thusleading to a pivoting, movement or resilient deformation of the firstfeedback element in circumferential direction or radial direction.

According to some examples, at least one of the first and the secondfeedback elements comprises a beveled section to engage with the otherone of the first and the second feedback elements. Typically, the firstfeedback element comprises a first beveled section and the secondfeedback element comprises a second beveled section. The first and thesecond beveled sections are configured to communicate with each other.The first and the second beveled sections may have complementary shapes.Hence, the first beveled section may communicate and may engage with thesecond beveled section as the first feedback element is subject to amovement relative to the second feedback element along the seconddirection. By means of the mutually corresponding first and secondbeveled sections, the movement of the first feedback element relative tothe second feedback element along the second direction leads to arespective movement, a pivoting or a resilient deformation of the firstfeedback element along the first direction. The degree and magnitude ofthe movement, the people to an angle or the resilient deformation isgoverned by the shape of the first and the second beveled sections.

In general it is sufficient when only one of the first and the secondfeedback elements comprises a single beveled section to engage with asurface or a portion of the other one of the first and the secondfeedback elements.

In some examples, the first and the second engaging sections areconfigured to positively engage when the first feedback element reachesthe initial state. By means of a positive engagement the first and thesecond feedback elements can be mutually fixed, e.g. with regards to thesecond direction. Moreover, by means of mutually corresponding and hencepositively engaging first and second engaging sections, a well-definedacoustically perceivable feedback can be provided.

In some examples, at least one of the first and the second engagingsections comprises a recess and the other one of the first and thesecond engaging section comprises a protrusion. The recess is configuredto receive the protrusion when the first feedback element reaches theinitial state. Typically, when the protrusion engages the recess it mayproduce and generate the acoustically perceivable sound and hence anacoustic feedback signal that is amplified by the free end section ofthe first feedback element and/or by the mechanical engagement with aseparate sound generator.

In some examples (e.g., examples without a separate sound generator), itis the mutual engagement of the first and the second engaging sections,e.g. the mutual engagement and mechanical interaction of the recess andthe protrusion that generates a sound that is amplified by the free endsection of the first feedback element. Typically, the free end sectionof the first feedback element is unitary or integrally formed with thefirst engaging section. In this way, a sufficient sound propagating andsound guiding structure can be provided from the first engaging sectiontowards the free end section.

In some examples, the injection device further comprises a housingaccommodating the acoustic feedback arrangement. The injection devicefurther comprises a dose tracking member movably arranged inside ormovably attached to the housing during dispensing of a dose of themedicament. At least one of the first and the second feedback elementsis connected to or integrated into the dose tracking member. The otherone of the first and the second feedback elements is then connected toor integrated into the housing. The first and second feedback elementsare connected to or integrated into the housing and the dose trackingmember so that the first engaging section of the first feedback elementengages with the second engaging section of the second feedback elementwhen the dose tracking member reaches an end of dose configuration atthe end of a dose dispensing procedure. In this way, the acousticfeedback arrangement provides an acoustic feedback signal at the end ofa dose dispensing procedure indicating to a patient or to a user of theinjection device that the process of expelling of a liquid medicamenthas terminated.

The dose tracking member may be movably arranged inside the housing ormay be movably attached to the housing also during setting of a dose.Hence, during the process of dose setting the dose tracking member maybe subject to a movement along a dose increasing direction. During asubsequent dose injection or dose dispensing procedure the dose trackingmember may be subject to a movement along an opposite direction, i.e.along a dose decrementing direction. Accordingly, the dose trackingmember is subject to a movement along the second direction during dosedispensing. It may be subject to an oppositely directed movement alongthe second direction during dose setting.

In some examples, the dose tracking member comprises one of a numbersleeve, a clutch member and the drive sleeve rotationally and/ortranslationally movable relative to the housing during setting of a doseor during dispensing of a dose of the medicament.

In some examples, the injection device further comprises a cartridgefilled with the medicament. The cartridge may be arranged inside thehousing of the injection device. The cartridge is typically sealed by abung movably arranged inside a barrel of the cartridge. The bungtypically forms a proximal seal of the cartridge while a distal end ofthe barrel of the cartridge is sealed by a further seal, e.g. by aseptum. The distal seal and hence the distal end of the cartridge istypically pierceable by a needle arrangement, such as a double-tippedinjection needle.

The injection device further comprises a piston rod movably arrangedinside and relative to the housing. The piston rod is typicallytranslationally displaceable relative to the housing in axial direction.It is operably engageable with the bung or piston of the cartridge forexpelling of a dose of the medicament from the cartridge, typicallythrough the double-tipped injection needle when attached to the distalend of the cartridge.

The injection device may be configured as a disposable device that isintended to be discarded in its entirety when the content of themedicament provided inside the cartridge has been used up. With adisposable device the cartridge is typically preassembled inside theinjection device when delivered to end consumers or patients. Theinjection device may be also configured as a reusable device providingreplacement of an empty cartridge after consumption of its content.Here, a distal housing portion, typically denoted as a cartridge holder,is disconnectable from a proximal housing component so as to enable areplacement of an empty cartridge.

In the present context a distal portion or the distal direction refersto that portion of the injection device that faces towards an injectionsite or towards biological tissue into which the medicament should beinjected. A proximal portion of the proximal direction refers to theopposite direction, facing away from a dispensing end of the injectiondevice.

The injection device is typically configured as a hand held injectionpen. The injection device may be implemented all mechanically. It may beuser actuatable in that sense that a user has to provide the entirety ofa driving force required to drive the bung of the cartridge in distaldirection. The injection device may be power assisted in that sense thatit comprises a mechanical or electrical energy storage reservoir that isconfigured to provide a driving force that is contributing to thedistally directed displacement of the button of the cartridge. In otherexamples the injection device may be implemented as an auto injectorand/or may comprise an electrically operated drive configured to providethe entirety of a driving force necessary to move the bung relative tothe barrel of the cartridge for the purpose of expelling of a dose ofthe medicament therefrom.

The term “drug” or “medicament”, as used herein, means a pharmaceuticalformulation containing at least one pharmaceutically active compound,

wherein in some embodiments the pharmaceutically active compound has amolecular weight up to 1500 Da and/or is a peptide, a proteine, apolysaccharide, a vaccine, a DNA, a RNA, an enzyme, an antibody or afragment thereof, a hormone or an oligonucleotide, or a mixture of theabove-mentioned pharmaceutically active compound,

wherein in some embodiments the pharmaceutically active compound isuseful for the treatment and/or prophylaxis of diabetes mellitus orcomplications associated with diabetes mellitus such as diabeticretinopathy, thromboembolism disorders such as deep vein or pulmonarythromboembolism, acute coronary syndrome (ACS), angina, myocardialinfarction, cancer, macular degeneration, inflammation, hay fever,atherosclerosis and/or rheumatoid arthritis,

wherein in some embodiments the pharmaceutically active compoundcomprises at least one peptide for the treatment and/or prophylaxis ofdiabetes mellitus or complications associated with diabetes mellitussuch as diabetic retinopathy,

wherein in some embodiments the pharmaceutically active compoundcomprises at least one human insulin or a human insulin analogue orderivative, glucagon-like peptide (GLP-1) or an analogue or derivativethereof, or exendin-3 or exendin-4 or an analogue or derivative ofexendin-3 or exendin-4.

Insulin analogues are for example Gly(A21), Arg(B31), Arg(B32) humaninsulin; Lys(B3), Glu(B29) human insulin; Lys(B28), Pro(B29) humaninsulin; Asp(B28) human insulin; human insulin, wherein proline inposition B28 is replaced by Asp, Lys, Leu, Val or Ala and wherein inposition B29 Lys may be replaced by Pro; Ala(B26) human insulin;Des(B28-B30) human insulin; Des(B27) human insulin and Des(B30) humaninsulin.

Insulin derivates are for example B29-N-myristoyl-des(B30) humaninsulin; B29-N-palmitoyl-des(B30) human insulin; B29-N-myristoyl humaninsulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin;B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl-ThrB29LysB30human insulin; B29-N-(N-palmitoyl-Υ-glutamyl)-des(B30) human insulin;B29-N-(N-lithocholyl-Υ-glutamyl)-des(B30) human insulin;B29-N-(ω-carboxyheptadecanoyl)-des(B30) human insulin andB29-N-(ω-carboxyheptadecanoyl) human insulin.

Exendin-4 for example means Exendin-4(1-39), a peptide of the sequenceH-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.

Exendin-4 derivatives are for example selected from the following listof compounds:

-   H-(Lys)4-des Pro36, des Pro37 Exendin-4(1-39)-NH2,-   H-(Lys)5-des Pro36, des Pro37 Exendin-4(1-39)-NH2,-   des Pro36 Exendin-4(1-39),-   des Pro36 [Asp28] Exendin-4(1-39),-   des Pro36 [IsoAsp28] Exendin-4(1-39),-   des Pro36 [Met(O)14, Asp28] Exendin-4(1-39),-   des Pro36 [Met(O)14, IsoAsp28] Exendin-4(1-39),-   des Pro36 [Trp(O2)25, Asp28] Exendin-4(1-39),-   des Pro36 [Trp(O2)25, IsoAsp28] Exendin-4(1-39),-   des Pro36 [Met(O)14 Trp(O2)25, Asp28] Exendin-4(1-39),-   des Pro36 [Met(O)14 Trp(O2)25, IsoAsp28] Exendin-4(1-39); or-   des Pro36 [Asp28] Exendin-4(1-39),-   des Pro36 [IsoAsp28] Exendin-4(1-39),-   des Pro36 [Met(O)14, Asp28] Exendin-4(1-39),-   des Pro36 [Met(O)14, IsoAsp28] Exendin-4(1-39),-   des Pro36 [Trp(O2)25, Asp28] Exendin-4(1-39),-   des Pro36 [Trp(O2)25, IsoAsp28] Exendin-4(1-39),-   des Pro36 [Met(O)14 Trp(O2)25, Asp28] Exendin-4(1-39),-   des Pro36 [Met(O)14 Trp(O2)25, IsoAsp28] Exendin-4(1-39),

wherein the group -Lys6-NH2 may be bound to the C-terminus of theExendin-4 derivative;

or an Exendin-4 derivative of the sequence

-   des Pro36 Exendin-4(1-39)-Lys6-NH2 (AVE0010),-   H-(Lys)6-des Pro36 [Asp28] Exendin-4(1-39)-Lys6-NH2,-   des Asp28 Pro36, Pro37, Pro38Exendin-4(1-39)-NH2,-   H-(Lys)6-des Pro36, Pro38 [Asp28] Exendin-4(1-39)-NH2,-   H-Asn-(Glu)5des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1-39)-NH2,-   des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1-39)-(Lys)6-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36 [Trp(O2)25, Asp28] Exendin-4(1-39)-Lys6-NH2,-   H-des Asp28 Pro36, Pro37, Pro38 [Trp(O2)25] Exendin-4(1-39)-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28]    Exendin-4(1-39)-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28]    Exendin-4(1-39)-NH2,-   des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36 [Met(O)14, Asp28] Exendin-4(1-39)-Lys6-NH2,-   des Met(O)14 Asp28 Pro36, Pro37, Pro38 Exendin-4(1-39)-NH2,-   H-(Lys)6-desPro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-NH2,-   des Pro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-Asn-(Glu)5 des Pro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-Lys6-des Pro36 [Met(O)14, Trp(O2)25, Asp28]    Exendin-4(1-39)-Lys6-NH2,-   H-des Asp28 Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25]    Exendin-4(1-39)-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Asp28]    Exendin-4(1-39)-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28]    Exendin-4(1-39)-NH2,-   des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28]    Exendin-4(1-39)-(Lys)6-NH2,-   H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28]    Exendin-4(S1-39)-(Lys)6-NH2,-   H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28]    Exendin-4(1-39)-(Lys)6-NH2;

or a pharmaceutically acceptable salt or solvate of any one of theafore-mentioned Exendin-4 derivative.

Hormones are for example hypophysis hormones or hypothalamus hormones orregulatory active peptides and their antagonists as listed in RoteListe, ed. 2008, Chapter 50, such as Gonadotropine (Follitropin,Lutropin, Choriongonadotropin, Menotropin), Somatropine (Somatropin),Desmopressin, Terlipressin, Gonadorelin, Triptorelin, Leuprorelin,Buserelin, Nafarelin, Goserelin.

A polysaccharide is for example a glucosaminoglycane, a hyaluronic acid,a heparin, a low molecular weight heparin or an ultra low molecularweight heparin or a derivative thereof, or a sulphated, e.g. apoly-sulphated form of the above-mentioned polysaccharides, and/or apharmaceutically acceptable salt thereof. An example of apharmaceutically acceptable salt of a poly-sulphated low molecularweight heparin is enoxaparin sodium.

Antibodies are globular plasma proteins (˜150 kDa) that are also knownas immunoglobulins which share a basic structure. As they have sugarchains added to amino acid residues, they are glycoproteins. The basicfunctional unit of each antibody is an immunoglobulin (Ig) monomer(containing only one Ig unit); secreted antibodies can also be dimericwith two Ig units as with IgA, tetrameric with four Ig units liketeleost fish IgM, or pentameric with five Ig units, like mammalian IgM.

The Ig monomer is a “Y”-shaped molecule that consists of fourpolypeptide chains; two identical heavy chains and two identical lightchains connected by disulfide bonds between cysteine residues. Eachheavy chain is about 440 amino acids long; each light chain is about 220amino acids long. Heavy and light chains each contain intrachaindisulfide bonds which stabilize their folding. Each chain is composed ofstructural domains called Ig domains. These domains contain about 70-110amino acids and are classified into different categories (for example,variable or V, and constant or C) according to their size and function.They have a characteristic immunoglobulin fold in which two β sheetscreate a “sandwich” shape, held together by interactions betweenconserved cysteines and other charged amino acids.

There are five types of mammalian Ig heavy chain denoted by α, δ, ε, γ,and μ. The type of heavy chain present defines the isotype of antibody;these chains are found in IgA, IgD, IgE, IgG, and IgM antibodies,respectively.

Distinct heavy chains differ in size and composition; α and γ containapproximately 450 amino acids and δ approximately 500 amino acids, whileμ and ε have approximately 550 amino acids. Each heavy chain has tworegions, the constant region (C_(H)) and the variable region (V_(H)). Inone species, the constant region is essentially identical in allantibodies of the same isotype, but differs in antibodies of differentisotypes. Heavy chains γ, α and δ have a constant region composed ofthree tandem Ig domains, and a hinge region for added flexibility; heavychains μ and ε have a constant region composed of four immunoglobulindomains. The variable region of the heavy chain differs in antibodiesproduced by different B cells, but is the same for all antibodiesproduced by a single B cell or B cell clone. The variable region of eachheavy chain is approximately 110 amino acids long and is composed of asingle Ig domain.

In mammals, there are two types of immunoglobulin light chain denoted byλ and κ. A light chain has two successive domains: one constant domain(CL) and one variable domain (VL). The approximate length of a lightchain is 211 to 217 amino acids. Each antibody contains two light chainsthat are always identical; only one type of light chain, κ or λ, ispresent per antibody in mammals.

Although the general structure of all antibodies is very similar, theunique property of a given antibody is determined by the variable (V)regions, as detailed above. More specifically, variable loops, threeeach the light (VL) and three on the heavy (VH) chain, are responsiblefor binding to the antigen, i.e. for its antigen specificity. Theseloops are referred to as the Complementarity Determining Regions (CDRs).Because CDRs from both VH and VL domains contribute to theantigen-binding site, it is the combination of the heavy and the lightchains, and not either alone, that determines the final antigenspecificity.

An “antibody fragment” contains at least one antigen binding fragment asdefined above, and exhibits essentially the same function andspecificity as the complete antibody of which the fragment is derivedfrom. Limited proteolytic digestion with papain cleaves the Ig prototypeinto three fragments. Two identical amino terminal fragments, eachcontaining one entire L chain and about half an H chain, are the antigenbinding fragments (Fab). The third fragment, similar in size butcontaining the carboxyl terminal half of both heavy chains with theirinterchain disulfide bond, is the crystalizable fragment (Fc). The Fccontains carbohydrates, complement-binding, and FcR-binding sites.Limited pepsin digestion yields a single F(ab′)2 fragment containingboth Fab pieces and the hinge region, including the H-H interchaindisulfide bond. F(ab′)2 is divalent for antigen binding. The disulfidebond of F(ab′)2 may be cleaved in order to obtain Fab′. Moreover, thevariable regions of the heavy and light chains can be fused together toform a single chain variable fragment (scFv).

Pharmaceutically acceptable salts are for example acid addition saltsand basic salts. Acid addition salts are e.g. HCl or HBr salts. Basicsalts are e.g. salts having a cation selected from alkali or alkaline,e.g. Na+, or K+, or Ca2+, or an ammonium ion N+(R1)(R2)(R3)(R4), whereinR1 to R4 independently of each other mean: hydrogen, an optionallysubstituted C1-C6-alkyl group, an optionally substituted C2-C6-alkenylgroup, an optionally substituted C6-C10-aryl group, or an optionallysubstituted C6-C10-heteroaryl group. Further examples ofpharmaceutically acceptable salts are described in “Remington'sPharmaceutical Sciences” 17. ed. Alfonso R. Gennaro (Ed.), MarkPublishing Company, Easton, Pa., U.S.A., 1985 and in Encyclopedia ofPharmaceutical Technology.

Pharmaceutically acceptable solvates are for example hydrates.

It will be further apparent to those skilled in the art that variousmodifications and variations can be made to the present disclosurewithout departing from the spirit and scope of the disclosure. Further,it is to be noted, that any reference numerals used in the appendedclaims are not to be construed as limiting the scope of the disclosure.

BRIEF DESCRIPTION OF THE FIGURES

In the following, embodiments of the drive mechanism and the injectiondevice are described in detail by making reference to the drawings, inwhich:

FIG. 1 schematically shows an example of an injection device;

FIG. 2 shows an exploded view of the components of the injection deviceof FIG. 1;

FIG. 3 shows a side view of an example of the acoustic feedbackarrangement with the first feedback arrangement in an initial state;

FIG. 4 shows a configuration of the acoustic feedback arrangementaccording to FIG. 3 with the first feedback arrangement in a biasedstate;

FIG. 5 shows a configuration of the acoustic feedback arrangementaccording to FIGS. 3 and 4 after the first feedback arrangement havingreturned into the initial state;

FIG. 6 shows a side view of another example with a separate soundgenerator and with the first feedback element in an initial state;

FIG. 7 shows the example according to FIG. 6 with the first feedbackelement in the biased state;

FIG. 8 shows the example according to FIGS. 6 and 7 when the firstfeedback element relaxes into the initial state and overshoots theinitial state thereby engaging with the sound generator; and

FIG. 9 shows the acoustic feedback arrangement of FIGS. 6 to 8 after thefirst feedback element has relaxed into its initial state.

DETAILED DESCRIPTION

The injection device 1 as shown in FIGS. 1 and 2 is a pre-filleddisposable injection device that comprises a housing 10 to which aninjection needle 15 can be affixed. The injection needle 15 is protectedby an inner needle cap 16 and either an outer needle cap 17 or aprotective cap 18 that is configured to enclose and to protect a distalsection of the housing 10 of the injection device 1. The housing 10 maycomprise and form a main housing part configured to accommodate a drivemechanism 8 as shown in FIG. 2. The injection device 1 may furthercomprise a distal housing component denoted as cartridge holder 14. Thecartridge holder 14 may be permanently or releasably connected to themain housing 10. The cartridge holder 14 is typically configured toaccommodate a cartridge 6 that is filled with a liquid medicament. Thecartridge 6 comprises a cylindrically-shaped or tubular-shaped barrel 25sealed in proximal direction 3 by means of a bung 7 located inside thebarrel 25. The bung 7 is displaceable relative to the barrel 25 of thecartridge 6 in a distal direction 2 by means of a piston rod 20. Adistal end of the cartridge 6 is sealed by a pierceable seal 26configured as a septum and being pierceable by a proximally directedtipped end of the injection needle 15. The cartridge holder 14 comprisesa threaded socket 28 at its distal end to threadedly engage with acorrespondingly threaded portion of the injection needle 15. Byattaching the injection needle 15 to the distal end of the cartridgeholder 14 the seal 26 of the cartridge 6 is penetrated therebyestablishing a fluid transferring access to the interior of thecartridge 6.

When the injection device 1 is configured to administer e.g. humaninsulin, the dosage set by a dial member 12 at a proximal end of theinjection device 1 may be displayed in so-called international units(IU), wherein 1 IU is the biological equivalent of about 45.5 μg of purecrystalline insulin ( 1/22 mg).

As shown further in FIGS. 1 and 2, the housing 10 comprises a dosagewindow 13 that may be in the form of an aperture in the housing 10. Thedosage window 13 permits a user to view a limited portion of a numbersleeve 80 that is configured to move when the dial member 12 is turned,to provide a visual indication of a currently set dose. The dial member12 is rotated on a helical path with respect to the housing 10 whenturned during setting and/or dispensing or expelling of a dose.

The injection device 1 may be configured so that turning the dosage knob12 causes a mechanical click sound to provide acoustical feedback to auser. The number sleeve 80, a clutch member and a drive sleeve 30mechanically interacts with a bung 7 in the insulin cartridge 6 via thepiston rod 20. When the needle 15 is stuck into a skin portion of apatient, and when the trigger 11 or injection button is pushed, theinsulin dose displayed in display window 13 will be ejected frominjection device 1. When the needle 15 of the injection device 1 remainsfor a certain time in the skin portion after the trigger 11 is pushed, ahigh percentage of the dose is actually injected into the patient'sbody. Ejection of an insulin dose may also cause a mechanical clicksound or a particular end-of dose sound, which is however different fromthe sounds produced when using the dial member 12.

In some embodiments, during delivery of the insulin dose, the dialmember 12 is turned to its initial position in an axial movement, thatis to say without rotation, while the number sleeve 80 is rotated toreturn to its initial position, e.g. to display a dose of zero units.

The injection device 1 may be used for several injection processes untileither the cartridge 6 is empty or the expiration date of the medicamentin the injection device 1 (e.g. 28 days after the first use) is reached.

Furthermore, before using injection device 1 for the first time, it maybe necessary to perform a so-called “prime shot” to remove air from thecartridge 6 and the needle 15, for instance by selecting two units ofthe medicament and pressing trigger 11 while holding the injectiondevice 1 with the needle 15 upwards. For simplicity of presentation, inthe following, it will be assumed that the ejected amounts substantiallycorrespond to the injected doses, so that, for instance the amount ofmedicament ejected from the injection device 1 is equal to the dosereceived by the user.

The expelling or drive mechanism 8 as illustrated in more detail in FIG.2 comprises numerous mechanically interacting components. A flange likesupport of the housing 10 comprises a threaded axial through openingthreadedly engaged with a first thread or distal thread 22 of the pistonrod 20. The distal end of the piston rod 20 comprises a bearing 21 onwhich a pressure foot 23 is free to rotate with the longitudinal axis ofthe piston rod 20 as an axis of rotation. The pressure foot 23 isconfigured to axially abut against a proximally facing thrust receivingface of the bung 7 of the cartridge 6. During a dispensing action thepiston rod 20 rotates relative to the housing 10 thereby experiencing adistally directed advancing motion relative to the housing 10 30 andhence relative to the barrel 25 of the cartridge 6. As a consequence,the bung 7 of the cartridge 6 is displaced in distal direction 2 by awell-defined distance due to the threaded engagement of the piston rod20 with the housing 10.

The piston rod 20 is further provided with a second thread 24 at itsproximal end. The distal thread 22 and the proximal thread 24 areoppositely handed.

There is further provided the drive sleeve 30 having a hollow interiorto receive the piston rod 20. The drive sleeve 30 comprises an innerthread threadedly engaged with the proximal thread 24 of the piston rod20. Moreover, the drive sleeve 30 comprises an outer threaded section 31at its distal end. The threaded section 31 is axially confined between adistal flange portion 32 and another flange portion 33 located at apredefined axial distance from the distal flange portion 32. Between thetwo flange portions 32, 33 there is provided a last dose limiting member35 in form of a semi-circular nut having an internal thread mating thethreaded section 31 of the drive sleeve 30.

The last dose limiting member 35 further comprises a radial recess orprotrusion at its outer circumference to engage with acomplementary-shaped recess or protrusion at an inside of the sidewallof the housing 10. In this way the last dose limiting member 35 issplined to the housing 10. A rotation of the drive sleeve 30 in a doseincrementing direction 4 or clockwise direction during consecutive dosesetting procedures leads to an accumulative axial displacement of thelast dose limiting member 35 relative to the drive sleeve 30. There isfurther provided an annular spring 40 that is in axial abutment with aproximally facing surface of the flange portion 33. Moreover, there isprovided a tubular-shaped clutch member 60. At a first end the clutchmember 60 is provided with a series of circumferentially directed sawteeth. Towards a second opposite end of the clutch member 60 there islocated a radially inwardly directed flange.

Furthermore, there is provided a dose dial sleeve also denoted as numbersleeve 80. The number sleeve 80 is provided outside of the spring 40 andthe clutch member 60 and is located radially inward of the housing 10. Ahelical groove 81 is provided about an outer surface of the numbersleeve 80. The housing 10 is provided with the dosage window 13 throughwhich a part of the outer surface of the number sleeve 80 can be seen.The housing 10 is further provided with a helical rib at an insidesidewall portion of an insert piece 62, which helical rib is to beseated in the helical groove 81 of the number sleeve 80. The tubularshaped insert piece 62 is inserted into the proximal end of the housing10. It is rotationally and axially fixed to the housing 10. There areprovided first and second stops on the housing 10 to limit a dosesetting procedure during which the number sleeve 80 is rotated in ahelical motion relative to the housing 10.

The dose member 12 in form of a dose dial grip is disposed about anouter surface of the proximal end of the number sleeve 80. An outerdiameter of the dose member 12 typically corresponds to and matches withthe outer diameter of the housing 10. The dose member 12 is secured tothe number 80 to prevent relative movement therebetween. The dose member12 is provided with a central opening.

The trigger 11, also denoted as dose button is substantially T-shaped.It is provided at a proximal end of the injection device 10. A stem 64of the trigger 11 extends through the opening in the dose member 12,through an inner diameter of extensions of the drive sleeve 30 and intoa receiving recess at the proximal end of the piston rod 20. The stem 64is retained for limited axial movement in the drive sleeve 30 andagainst rotation with respect thereto. A head of the trigger 11 isgenerally circular. The trigger side wall or skirt extends from aperiphery of the head and is further adapted to be seated in aproximally accessible annular recess of the dose member 12.

To dial a dose a user rotates the dose member 12. With the spring 40also acting as a clicker and the clutch member 60 engaged, the drivesleeve 30 the spring or clicker 40, the clutch member 60 and the numbersleeve 80 rotate with the dose member 12. Audible and tactile feedbackof the dose being dialed is provided by the spring 40 and by the clutchmember 60. Torque is transmitted through saw teeth between the spring 40and the clutch member 60. The helical groove 81 on the number sleeve 80and a helical groove in the drive sleeve 30 have the same lead. Thisallows the number sleeve 80 to extend from the housing 10 and the drivesleeve 30 to climb the piston rod 20 at the same rate. At a limit oftravel a radial stop on the number sleeve 80 engages either with a firststop or a second stop provided on the housing 10 to prevent furthermovement. Rotation of the piston rod 20 is prevented due to the opposingdirections of the overall and driven threads on the piston rod 20.

The last dose limiting member 35 keyed to the housing 10 is advancedalong the threaded section 31 by the rotation of the drive sleeve 30.When a final dose configuration or position is reached, a radial stopformed on a surface of the last dose limiting member 35 abuts a radialstop on the flange portion 33 of the drive sleeve 30, preventing both,the last dose limiting member 35 and the drive sleeve 30 from rotatingfurther.

Should a user inadvertently dial beyond the desired dosage, theinjection device 1, configured as a pen-injector allows the dosage to bedialed down without dispense of the medicament from the cartridge 6. Forthis the dose member 12 is simply counter-rotated. This causes thesystem to act in reverse. A flexible arm of the spring or clicker 40then acts as a ratchet preventing the spring 40 from rotating. Thetorque transmitted through the clutch member 60 causes the saw teeth toride over one another to create the clicks corresponding to dialed dosereduction. Typically, the saw teeth are so disposed that acircumferential extent of each saw tooth corresponds to a unit dose.

When the desired dose has been dialed the user may simply dispense theset dose by depressing the trigger 11. This displaces the clutch member60 axially with respect to the number sleeve 80 causing dog teeththereof to disengage. However, the clutch member 60 remains keyed inrotation to the drive sleeve 30. The number sleeve 80 and the dosemember 12 are now free to rotate in accordance with the helical groove81.

The axial movement deforms the flexible arm of the spring 40 to ensurethe saw teeth cannot be overhauled during dispense. This prevents thedrive sleeve 30 from rotating with respect to the housing 10 though itis still free to move axially with respect thereto. The deformation issubsequently used to urge the spring 40 and the clutch member 60 backalong the drive sleeve 30 to restore the connection between the clutchmember 60 and the number sleeve 80 when the distally directed dispensingpressure is removed from the trigger 11.

The longitudinal axial movement of the drive sleeve 30 causes the pistonrod 20 to rotate through the through opening of the support of thehousing 10, thereby to advance the bung 7 in the cartridge 6. Once thedialed dose has been dispensed, the number sleeve 80 is prevented fromfurther rotation by contact of a plurality of members extending from thedose member 12 with a corresponding plurality of stops. A zero doseposition is finally determined by the abutment of one of axiallyextending edges of members of the number indicating sleeve 80 with acorresponding stop of the housing 10.

The dose setting mechanism 9 as illustrated in FIG. 2 comprises at leastthe dial member 12 and the number sleeve 80. As the dial member 12 isrotated during and for setting of a dose the number sleeve 80 starts torotate relative to the housing 10 along a helical path as defined by thethreaded engagement of its outer thread or helical groove 81 with acorrespondingly shaped threaded section at the inside surface of thehousing 10.

During dose setting and when the drive mechanism 8 or the dose settingmechanism 9 is in the dose setting mode the drive sleeve 30 rotates inunison with the dial member 12 and with the number sleeve 80. The drivesleeve 30 is threadedly engaged with the piston rod 20, which duringdose setting is stationary with regard to the housing 10. Accordingly,the drive sleeve 30 is subject to a screwing or helical motion duringdose setting. The drive sleeve 30 starts to travel in proximal directionas the dose dial member is rotated in a dose incrementing direction 4,e.g. in a clockwise direction. For adjusting of or correcting a size ofa dose the dial member 12 is rotatable in an opposite direction, hencein a dose decrementing direction 5, e.g. counterclockwise.

At least one of the drive sleeve 30, the clutch member 60 and the numbersleeve 80 serves as a dose tracking member 50 that may comprise atracking stop feature 51. In some examples, such as the example asillustrated for instance in FIG. 2, one of the flanges 32 or 33 providesand coincides with a tracking stop feature 51 of the dose trackingmember 50.

The dose setting and expelling mechanism or drive mechanism 8 asdescribed above is only exemplary for one of a plurality of differentlyconfigured drive mechanisms that are generally implementable in adisposable pen-injector and with an acoustic feedback arrangement aswill be described below. The drive mechanism as described above isexplained in more detail e.g. in WO2004/078239A1, WO 2004/078240A1 or WO2004/078241A1 the entirety of which being incorporated herein byreference.

The injection device 1 further comprises an acoustic feedbackarrangement 150, 250 as will be explained in greater detail with regardto FIGS. 3 to 9. In general, at least one of the drive sleeve 30, theclutch member 60 and the number sleeve 80 may serve and provide a dosetracking member 50 having one of a first and a second feedback element152, 154 of the acoustic feedback arrangement 150 as illustrated inFIGS. 3 to 5. A stationary component of the injection device 1, such asthe housing 10 or the insert piece 62 may have or may be equipped withthe other one of a first and the second feedback element 152, 154 of theacoustic feedback arrangement 150.

As illustrated by the sequence of FIGS. 3, 4 and 5 the first feedbackelement 152 is movable relative to the second feedback element 154. Thefirst feedback element 152 may be translationally and/or rotationallymovable relative to the second feedback element 154 with regards to asecond direction d2. As it is immediately apparent from a comparison ofFIGS. 3 and 4 the first feedback element 152 is resiliently deformablewith regards to a first direction d1. In the presently illustratedexample the first direction d1 and the second direction d2 are orientedperpendicular with regard to each other. The first direction d1 may beoriented radially inwardly or radially outwardly with regards to theoverall tubular shape of the housing 10. The first direction d1 may bealso oriented in circumferential or tangential direction with regards tothe overall tubular shape of the housing 10. The second direction d2 maybe oriented in axial direction with regards to the tubular shape of thehousing 10. It may coincide with the distal direction 2 or with theproximal direction 3 as indicated in FIG. 1.

It is also conceivable, that the second direction d2 is orientedtangentially or circumferentially and that the first direction d1 isoriented radially inwardly or radially outwardly.

In some examples, such as the examples of FIGS. 3 to 5, the firstfeedback element 152 is slidably and continuously displaceable relativeto the second feedback element 154. The first feedback element 152comprises a first engaging section 156, e.g. in form of a recess 173.Correspondingly, the second feedback element 154 comprises a secondengaging section 158, e.g. in form of a protrusion 174. The protrusion174 is shaped to fit into the recess 173. In this way and when reachingan end-of-dose configuration as shown in FIG. 5, the protrusion 174 isentirely received in the recess 173. The configuration as shown in FIG.5 corresponds to a zero dose configuration, at the end of a dosedispensing procedure conducted by the injection device

Prior to reach the zero dose configuration the first engaging section156 of the first feedback element 152 approaches the second engagingsection 158 of the second feedback element 154. While approaching thesecond engaging section 158 the first feedback element 152 is subject toa resilient deformation. Since the first and second feedback elements152, 154 are fixed inside the housing or are fixedly attached to thehousing 10 with regard to the first direction d1 a movement of the firstfeedback element 152 towards the zero dose configuration is accompaniedby a resilient deformation at least of a portion of the first feedbackelement 152.

As shown in FIG. 4, a first beveled section 171 at a side face of thefirst feedback element 152 facing towards the second feedback element154 gets in abutment with the protrusion 174. The protrusion 174 of thesecond feedback element 154 comprises a correspondingly shaped secondbeveled section 172. As the beveled sections 171, 172 of the first andthe second feedback elements 152, 164 mutually engage the first feedbackelement 152 become subject to a resilient deformation along the firstdirection d1.

During the course of a further movement of the first feedback element152 along the second direction d2 relative to the second feedbackelement 154, the degree of resilient deformation increases until thefirst engaging section 156, e.g. the recess 173 of the first feedbackelement 152 engages with the second engaging section 158, e.g. theprotrusion 174 of the second feedback element 154. During the resilientdeformation of the first feedback element 152 along the first directiond1 the first feedback element 152 is mechanically biased or pre-tensed.As indicated in FIG. 4, the first feedback element 152 is in a biasedstate b. As soon as the first and the second engaging sections 156, 158are in a position to mutually engage, the biased section or theresiliently deformed section of the first feedback element 152 suddenlydislodges and returns into an initial state i as shown in FIGS. 3 and 5.

The first feedback element 152 comprises a resiliently deformable body151 that is deformable from the initial state i as shown in FIG. 3 intoa biased state b as shown in FIG. 4. The body 151 provides a resilientrestoring force. As the first feedback element 152 returns into itsinitial state i under the effect of the resilient restoring force itproduces an audible sound or an audible noise when engaging with thesecond feedback element 154.

As it is further shown in FIGS. 3 to 5 the first feedback element 152,in particular its body 151 comprises a free end section 155 that islocated at a distance from the first engaging section 156. The free endsection 155 is free of contact to the second feedback element 154 ineither configuration. The free end section 155 is permanently void ofany mechanical contact to the second feedback element 154 or to anyother component of the injection device 1. In this way, the free endsection 155 is free to vibrate as the first engaging section 156 audiblyengages with the second engaging section 158. In this way, a noise or asound generated by the mutual and mechanical interaction of the firstand the second engaging sections 156, 158 is not only transferabletowards and into the free end section 155. Due to the freely vibratingsuspension of the free end section 155, an acoustic noise or an acousticsound generated by the first and the second engaging sections 156, 158can be enhanced and amplified by the vibration of the free end section155. At least, the free end section 155 may provide a kind of a reverbeffect and a comparatively long-lasting and comparatively slowlyattenuating characteristic end-of-dose sound can be generated.

The free end section 155 of the first feedback element 152 may comprisea curved section 153. The curved section 153 may comprise an arc-shape,wherein in the initial state i of the first feedback element 152 a freeend or a contact surface 159 at the free end of the free end section 155is approximately located at the same level with regards to the firstdirection d1 than a surface portion 175 of a base portion 177 of thefirst feedback element 152. Here, the surface portion 175 is located ona side of the first feedback element that faces towards the secondfeedback element as seen along the first direction d1.

In the biased state b as shown in FIG. 4 the free end section 155 andthe contact surface 159 comprise a larger distance to a surface portion176 of the second feedback element 154 that faces towards the firstfeedback element 152. As the first and the second feedback elements 152,154 mutually engage with their first and second engaging sections 156,158 the surface portions 175, 176 of the first and the second feedbackelements 152, 154 mutually approach compared to the biased state of thefirst feedback element 152.

At least a portion of the free end section 155, in particular the veryend of the free end section 155 may comprise a hollow portion 157. Inthat part of the free end section of the body 151 of the first feedbackelement 152 may be of substantially hollow shape. A hollow shape of thecurved section 153 of the free end section 155 may further enhance anacoustic amplification of an audible for acoustic signal generated bythe mechanical engagement of the first and the second engaging sections156, 158.

Additionally or alternatively it is also conceivable, that the surfaceportions 175, 176 of the first and the second feedback elements 152, 154that face towards each other mutually and audibly engage as the firstfeedback element 152 returns from the biased state b into the initialstate i. As indicated in FIG. 5, the surface portion 175 of the baseportion 177 of the first feedback element 152 almost entirely overlapswith the surface portion 176 of the second feedback element 154. Due toa large overlap, a correspondingly loud or intense acoustic signal canbe generated. The acoustic signal may resemble a whip sound or a crackof a whip. Also this sound and the respective sound propagation can beacoustically amplified and enhanced by the shape and the freelyvibrating free end section 155 of the first feedback element 152.

In some examples, such as the example of an acoustic feedbackarrangement 150 according to FIGS. 3 to 5, the first engaging section156 forms or contributes to a sound generator 160 that is configured andenabled to produce an audible sound as a zero dose configuration of thefirst and the second feedback elements 152, 154 has been reached. Thefree end section 155 of the first feedback element 152 then serves as anacoustic amplification means. In effect and in comparison to solutionsknown in the art a comparatively load and rather specific acousticfeedback can be provided as the drive mechanism 8 or the dose settingmechanism 9 arrives at the end-of-dose configuration.

In some examples, such as the example of another acoustic feedbackarrangement 250 as shown in FIGS. 6 to 9, the first and the secondfeedback elements 152, 154 remain substantially unchanged compared tothe example of the acoustic feedback arrangement 150 as illustrated inFIGS. 3 to 5. But there, a separate sound generator 260 is provided. Thesound generator 260 may be located at a well-defined position inside thehousing 10 of the injection device 1. Alternatively, the sound generator260 may be connected to or may be integrally formed with the secondfeedback element 154. Further alternatively, It may be also connected toor integrally formed with the first feedback element 152, e.g. with thebase portion 177 thereof.

Upon reaching a zero dose configuration as shown in FIGS. 8 and 9 thefree end section 155 of the first feedback element 152 strikes the soundgenerator 260 in order to generate a distinct and well-defined acousticfeedback signal. The sound generator 260 may comprise a bell shape ormay provide a bell function when hit by the contact surface 159 of thefree end section 155 of the first feedback element 152. Here, theelastically deformable first feedback element 152 provides the functionof a clapper, of a tongue or of a mallet to strike the sound generator260. As shown in FIG. 7, the free end section 155 of the first feedbackelement 152 is elastically biased or pre-tensed along the firstdirection d1 away from the sound generator 260.

As the end of dose configuration as shown in FIG. 8 has been reached,the pre-tensed and biased free end section 155 is abruptly dislodged.Under the effect of a restoring force the base portion 177 of the firstfeedback element 152 approaches the second feedback element 154. Thefirst and the second feedback elements 152, 154 mutually engage andalign with their base portions 177. Since the free end section 155protrudes from an end section of the second feedback element 154 alongthe second direction d2 the free end section 155 overshoots the initialstate i as shown in FIG. 9 and hits the sound generator 260. Whenreaching the initial state i, in which the mechanical vibration of thefree end section 155 has been attenuated the free end section 155 andthe contact surface 159 thereof are located at a well-defined distance Dfrom the sound generator 260. In this way, the sound generator 260 maystill vibrate to generate a long-lasting acoustic feedback, e.g. with areverb effect. The sound generator 260 may be vibrationally supported orsuspended inside the housing 10.

In some examples, such as the example according to FIGS. 6 to 9, is notgenerally necessary, that the second feedback element 154 is located onthe same side of the first feedback element 152 as the sound generator260. It is generally conceivable, that the second feedback element 154is located at a side of the first feedback element 152 that faces awayfrom the sound generator 260. However, the first and the second feedbackelements 152, 154 comprise first and second and mutually correspondingengaging sections 156, 158 so that the first feedback element 154becomes resiliently deformed, moved of pivoted along the first directionin response to a movement of the first feedback element 152 relative tothe second feedback element 154.

Even though it is illustrated in FIGS. 6 to 9 that the first feedbackelement 152 is displaceable along the second direction d2 relative tothe sound generator 260, while the sound generator 260 is fixed relativeto the second feedback element 154 it is also conceivable, that thefirst feedback element 152 is fixed to the sound generator 260 withregards to the second direction d2 and that the first feedback element152 is only displaceable or pivotable or deformable relative to thesound generator 260 with regard to the first direction d1. Then, it maybe the second feedback element 154 that is displaceable relative to thefirst feedback element 152 with regard to one of the first direction d1and the second direction d2.

Even though with the illustrated example the first feedback element 152is resiliently deformable it is likewise conceivable, that the firstfeedback element 152 is pivotally or movably displaced inside thehousing 10 along the first direction d1 so as to swivel or to pivotbetween the initial state i and the biased state b. In that case, thefirst feedback element may be coupled with a separate restoring element,such as a spring element or the like resiliently deformable elementbeing deformable against a restoring force.

LIST OF REFERENCES

1 injection device

2 distal direction

3 proximal direction

4 dose incrementing direction

5 dose decrementing direction

6 cartridge

7 bung

8 drive mechanism

9 dose setting mechanism

10 housing

11 trigger

12 dial member

13 dosage window

14 cartridge holder

15 injection needle

16 inner needle cap

17 outer needle cap

18 protective cap

20 piston rod

21 bearing

22 first thread

23 pressure foot

24 second thread

25 barrel

26 seal

28 threaded socket

30 drive sleeve

31 threaded section

32 flange

33 flange

35 last dose limiting member

40 spring

50 dose tracking member

51 tracking stop feature

60 clutch member

62 insert piece

63 stop feature

64 stem

80 number sleeve

81 groove

150 acoustic feedback arrangement

151 body

152 feedback element

153 curved section

154 feedback element

155 free end section

156 engaging section

157 hollow portion

158 engaging section

159 contact surface

160 sound generator

171 beveled section

172 beveled section

173 recess

174 protrusion

175 surface portion

176 surface portion

177 base portion

250 acoustic feedback arrangement

260 sound generator

1. An injection device for setting and injecting of a dose of amedicament, the injection device comprising: an acoustic feedbackarrangement comprising: a first feedback element having a first engagingsection and having a free end section located at a predetermineddistance from the first engaging section; a second feedback elementhaving a second engaging section configured to engage with the firstengaging section; wherein the first feedback element is movable,pivotable or resiliently deformable along a first direction relative tothe second feedback element from an initial state towards a biasedstate; and a sound generator formed by the first engaging section oraudibly engageable with the free end section of the first feedbackelement.
 2. The injection device according to claim 1, wherein the firstengaging section is configured to audibly engage with the secondengaging section when the first feedback element returns from the biasedstate to the initial state.
 3. The injection device according to claim1, wherein the free end section of the first feedback element is free ofcontact to any other component of the injection device when the firstfeedback element is in the initial state.
 4. The injection deviceaccording to claim 1, wherein the free end section of the first feedbackelement is transferable to a vibrational state.
 5. The injection deviceaccording to claim 1, wherein the first feedback element comprises abody having at least one hollow portion at the free end section.
 6. Theinjection device according to claim 1, wherein the first feedbackelement comprises a curved section located between the first engagingsection and the free end section.
 7. The injection device according toclaim 1, wherein the free end section comprises a contact surfaceconfigured to audibly engage with the sound generator when the firstfeedback element returns from the biased state to the initial state. 8.The injection device according to claim 1, wherein the sound generatoris transferable to a vibrational state through engagement with the firstfeedback element when the sound generator is audibly engageable with thefree end section of the first feedback element.
 9. The injection deviceaccording to claim 1, wherein the second feedback element is configuredto transfer the first feedback element from the initial state towardsthe biased state.
 10. The injection device according to claim 1, whereinat least one of the first and the second feedback elements comprises abeveled section to engage with the other one of the first and the secondfeedback elements.
 11. The injection device according to claim 1,wherein the first and the second engaging sections are configured topositively engage when the first feedback element reaches the initialstate.
 12. The injection device according to claim 1, wherein one of thefirst and the second engaging sections comprises a recess and whereinthe other one of the first and the second engaging sections comprises aprotrusion, wherein the recess is configured to receive the protrusionwhen the first feedback element reaches the initial state.
 13. Theinjection device according to claim 1, further comprising a housingaccommodating the acoustic feedback arrangement and a dose trackingmember movably arranged inside the housing or movably attached to thehousing during dispensing of a dose of the medicament, wherein one ofthe first and the second feedback elements is connected to or integratedinto the dose tracking member and wherein the other one of the first andthe second feedback elements is connected to or integrated into thehousing.
 14. The injection device according to claim 13, wherein thedose tracking member comprises one or more of a number sleeve, a clutchmember, or a drive sleeve one or both of rotationally or translationallymovable relative to the housing during setting of a dose or duringdispensing of a dose of the medicament.
 15. The injection deviceaccording to claim 13, further comprising: a cartridge filled with themedicament, wherein the cartridge is arranged inside the housing andsealed by a bung movably arranged inside a barrel of the cartridge; anda piston rod movably arranged inside and relative to the housing andoperably engageable with the bung for expelling of a dose of themedicament from the cartridge.
 16. The injection device according toclaim 2, wherein the free end section of the first feedback element isfree of contact to any other component of the injection device when thefirst feedback element is in the initial state.
 17. The injection deviceaccording to claim 3, wherein the free end section of the first feedbackelement is transferable to a vibrational state.
 18. The injection deviceaccording to claim 4, wherein the first feedback element comprises abody having at least one hollow portion at the free end section.
 19. Theinjection device of claim 14, further comprising: a cartridge configuredto be filled with the medicament, wherein the cartridge is arrangedinside the housing and sealed by a bung movably arranged inside a barrelof the cartridge; and a piston rod movably arranged inside and relativeto the housing and operably engageable with the bung for expelling of adose of the medicament from the cartridge.
 20. The injection device ofclaim 19, wherein the cartridge is at least partially filled with themedicament.